Drug interactions: Most experiences of clinically important drug interactions occurring with the barbiturates have involved phenobarbital.

pentobarbital will lessen the extent or effect of budesonide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.

pentobarbital will minimize the extent or effect of theophylline by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.

Contraindicated (one)pentobarbital will decrease the extent or effect of roflumilast by impacting hepatic/intestinal enzyme CYP3A4 metabolism.

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pentobarbital will decrease the extent or effect of roflumilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration not encouraged; strong cytochrome P450 enzyme inducers reduce systemic publicity to roflumilast and may reduce the therapeutic effectiveness

pentobarbital will decrease the level or effect of etravirine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

pentobarbital will lessen the extent or effect of buspirone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.

pentobarbital will minimize the extent or effect of felodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.

Estradiol, estrone, progesterone and other steroidal hormones: Pretreatment with or concurrent administration of phenobarbital may possibly minimize the effect of estradiol by increasing its metabolism.

pentobarbital will decrease the level or effect of fosaprepitant by here impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.

pentobarbital will decrease the level or effect of zonisamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unfamiliar.

pentobarbital will lessen the level or effect of alosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unknown.

Despite the fact that not suggested like a plan method, hemodialysis may very well be used in serious barbiturate intoxications or If your patient is anuric or in shock. Affected person need to be rolled from side to side each half an hour. Antibiotics really should be given if pneumonia is suspected. Proper nursing care to stop hypostatic pneumonia, decubiti, aspiration, and other issues of clients with altered states of consciousness.